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MRNA expression profile in the liver after overexpressed tsRNA-Glu-CTC oligos in C57BL/6 mice with mRNA-seq method

ABSTRACT: Purpose: To reveal mRNA profiles in the liver using mRNA-seq method. Methods: 8 week old C57BL/6 male mice were injected Control Oligos and tsRNA-Glu-CTC oligos for two weeks. Liver RNA was extracted with Trizol methods. Results:mRNA-seq revealed upregulation of lipids metabolism related genes in overexpressed tsRNA-Glu-CTC oligos mice. Importantly, cholesterol synthesis key genes SREBP2 and HMGCR are significantly upregulation.

ORGANISM(S): Mus musculus

PROVIDER: GSE299864 | GEO | 2025/07/02

REPOSITORIES: GEO

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