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MRNA expression changes after SAM CRISPRa activator (MCP-p65AD-HSF1AD) expression in the primary effusion lymphoma cell line BC-3

ABSTRACT: CRISPR-based transcriptional activation (CRISPRa) has extensive research and clinical potential. In our related work, we showed that commonly used CRISPRa systems can exhibit pronounced cytotoxicity. Here, we investigated mRNA expression changes after the inducible expression of a fusion protein that is commonly used for CRISPRa, including the activation domains (ADs) of the transcription factors p65 and HSF1, components of the synergistic activation mediator (SAM) CRISPRa system.

ORGANISM(S): Homo sapiens

PROVIDER: GSE299931 | GEO | 2025/07/30

REPOSITORIES: GEO

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mRNA expression changes after SAM CRISPRa activator (MCP-p65AD-HSF1AD) expression in the primary effusion lymphoma cell line BC-3

Project description:mRNA expression changes after SAM CRISPRa activator (MCP-p65AD-HSF1AD) expression in the primary effusion lymphoma cell line BC-3

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