Effect of hepatocytic RKIP depletion on HFD-induced MASLD

ABSTRACT: High-fat diet (HFD) is a risk factor for metabolic dysfunction-associated steatotic liver disease (MASLD), yet the molecular pathways that connect dietary fats to liver dysfunction remain unclear. Hepatocyte-specific RKIP depletion in male mice exacerbates ER stress, resulting in lipid droplets accumulation and MASLD progression.

ORGANISM(S): Mus musculus

PROVIDER: GSE300123 | GEO | 2025/09/03

REPOSITORIES: GEO