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Loss of WWOX Drives Cutaneous Squamous Cell Carcinoma (cSCC) through Regulating EMT

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE300270 | GEO | 2026/04/01

REPOSITORIES: GEO

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Loss of WWOX Drives Cutaneous Squamous Cell Carcinoma (cSCC) through Regulating EMT [RNA-Seq]

Project description:Cutaneous Squamous Cell Carcinoma (cSCC) is the second most common skin cancer, with a rising incidence in recent years. Through protein-protein interactions, the WW domain-containing oxidoreductase (WWOX) has been found to be a key player in many cellular processes, including DNA repair, apoptosis, metabolism, and transcriptional regulation. WWOX loss has been reported in many malignancies, including cSCC, suggesting a tumor suppressor role, but its function as a skin cancer antagonist and the underlying molecular mechanisms are not yet fully understood. To better understand WWOX's role in cSCC, we generated K14-Cre;Wwox;Trp53 conditional knock-out mice, leading to the development of cSCC. Strikingly, mice with ablated WWOX developed cSCC with increased penetrance and earlier onset. Characterization of cSCC morphology, immune markers, and transcriptional signatures revealed poorly differentiated cSCC with epithelial-to-mesenchymal transition (EMT) traits in tumors lacking WWOX compared to their controls. The hyperplastic phenotype of the epidermis in conditionally Wwox-knock-out mice was observed at an early age and impacted the surrounding microenvironment as well. Based on WWOX's known interaction with and stabilization of the transcription factor p63, we proposed that epidermal WWOX loss reduces p63 levels, destabilizing the tissue's epithelial integrity. Indeed, our findings confirmed this mechanism, demonstrating that diminished p63 impairs the epidermal protective barrier and accelerates the progression of aggressive cSCC. The WWOX-p63 correlation was also observed in human cSCC samples, inversely related to tumor stage. These findings were further supported in keratinocytes and cSCC human cell line models, where WWOX deficiency led to reduced p63 expression, concomitant with enhanced tumorigenic potential and migratory capacity.

2026-04-13 | GSE300269 | GEO

Loss of WWOX Drives Cutaneous Squamous Cell Carcinoma (cSCC) through Regulating EMT [ChIP-Seq]

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Loss of WWOX Drives Cutaneous Squamous Cell Carcinoma (cSCC) through Regulating EMT

Project description:Loss of WWOX Drives Cutaneous Squamous Cell Carcinoma (cSCC) through Regulating EMT

| PRJNA1279994 | ENA

Loss of WWOX Drives Cutaneous Squamous Cell Carcinoma (cSCC) through Regulating EMT [RNA-Seq]

Project description:Loss of WWOX Drives Cutaneous Squamous Cell Carcinoma (cSCC) through Regulating EMT [RNA-Seq]

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Loss of WWOX Drives Cutaneous Squamous Cell Carcinoma (cSCC) through Regulating EMT [ChIP-Seq]

Project description:Loss of WWOX Drives Cutaneous Squamous Cell Carcinoma (cSCC) through Regulating EMT [ChIP-Seq]

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miR-365 promotes cutaneous squamous cell carcinoma (CSCC) through targeting nuclear factor I/B (NFIB).

Project description:Aberrant expression of microRNAs plays vital roles in tumor development and progression. As transcription factors (TFs) are the critical components of signaling cascades, specific targeting effects of microRNAs to specific TFs may determine the role of microRNAs in different cancers. In this study, we identified Nuclear Factor I/B (NFIB) as one of the targets of miR-365 which was previously verified as an onco-miR in cutaneous squamous cell carcinoma (CSCC). Down-regulation of NFIB was a general feature in both CSCC cell lines and tumors from patients which show drastically up-regulated miR-365 expression levels. The siRNA-based knockdown of NFIB mimic the carcinogenic transformation of normal cells by ectopically expression of miR-365 which indicates depletion of NFIB is necessary for miR-365 to exert its pro-carcinogenic function. NFIB may represent a functional barrier targeted by miR-365 to the development of CSCC. Further studies also discovered a conserved feedback regulatory circuitry formed by NFIB and miR-365 in CSCC development which may be potentially utilized as therapeutic target to improve the clinical CSCC treatment.

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AK144841 in Cutaneous Squamous Cell Carcinoma (cSCC)

Project description:This SuperSeries is composed of the SubSeries listed below.

2017-06-07 | GSE89516 | GEO

KS-cSCC-1 and KS-cSCC-2: two novel cutaneous squamous cell carcinoma cell lines established from Japanese patients

Project description: Not available

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circRNA expression in cutaneous squamous cell carcinoma (cSCC)

Project description:Punch biopsies from patients with cSCC (n=3) and non-lesional skin (n=3) were included in the study. Microarray based circRNA expression profiles were acquired using Arraystar circRNA Arrays V. 2.0 screening for 13.617 distinct human circRNA candidates. We identified circRNAs differentially expressed in cSCC compared to non-lesional skin (control).

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Project description:AK144841 in Cutaneous Squamous Cell Carcinoma (cSCC)

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