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Investigating milk-derived extracellular vesicles as mediators of maternal stress and environmental intervention [miRNA-seqHippo]

ABSTRACT: It was our goal to identify changes in miRNA expression in the neonatal offspring hippocampus (on postnatal [P]10), after maternal immune activation in lactating Sprague-Dawley rat mothers.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE300302 | GEO | 2025/11/14

REPOSITORIES: GEO

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Investigating milk-derived extracellular vesicles as mediators of maternal stress and environmental intervention [miRNA-seqMilk]

Project description:It was our goal to identify changes in milk-derived extracellular vesicle miRNA cargos after maternal immune activation in lactating Sprague-Dawley rat mothers.

2025-11-14 | GSE300818 | GEO

The effects of environmental enrichment on maternal nurturance, lactation quality, and offspring social behavior

Project description:It was our goal to discern the effects of environemental enrichement on quality of mRNA in milk from Sprague-Dawley rat mothers.

2022-07-01 | GSE200249 | GEO

Maternal immune activation during the mid-lactational period affects nutritional milk quality and adolescent offspring sensory processing in male and female rats

Project description:It was our goal to discern the effects of maternal immune activation on quality of mRNA in milk from Sprague-Dawley rat mothers.

2022-07-01 | GSE202525 | GEO

Investigating milk-derived extracellular vesicles as mediators of maternal stress and environmental intervention [miRNA-seqMilk]

Project description:Investigating milk-derived extracellular vesicles as mediators of maternal stress and environmental intervention [miRNA-seqMilk]

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Investigating milk-derived extracellular vesicles as mediators of maternal stress and environmental intervention [miRNA-seqHippo]

Project description:Investigating milk-derived extracellular vesicles as mediators of maternal stress and environmental intervention [miRNA-seqHippo]

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Small RNA-sequencing of plasma exosome-enriched extracellular vesicles derived miRNAs from lactating mothers with type 1 diabetes and lactating healthy mothers

Project description:Previous studies have shown that the circulating miRNA signatures are altered in plasma-derived extracellular vesicles of individuals with type 1 diabetes. These alterations in the miRNA profile could serve as a potential biomarker applicable in clinical practice for monitoring disease status in lactating mothers with type 1 diabetes during the postpartum period. In the present study, we investigate the profiles of extracellular vesicle-derived miRNAs in circulation in a cohort of lactating mothers with and without type 1 diabetes.

2021-09-23 | E-MTAB-10458 | biostudies-arrayexpress

Differential gene expression in lactating rats compared against age matched virgin controls

Project description:Gene level analysis of lactating day 10-11 16h Sprague-Dawley dams compared against age matched virgins. Lactation is a time of significantly increased energy demands imposed by the suckling young that requires a proportional adjustment in the ability of the lactating dam to absorb nutrients and to synthesize critical biomolecules to meet the dietary needs of both the offspring and the dam. We have shown an increase in the size and hydrophobicity of the bile acid pool during lactation [1], implying an increased absorption and disposition of lipids, sterols, nutrients, and xenobiotics. In order to investigate changes at the level of mRNA, we utilized an exon array and calculated gene level summaries to investigate changes in gene expression in the liver, duodenum, jejunum, and ileum of lactating dams when compared against age-matched virgin controls. Affymetrix Rat Exon 1.0ST arrays were used to determine expression of genes in the livers and small intestines of day 10-11 lactating Sprague Dawley rats and compared against virgins of comparable age.

2010-11-21 | E-GEOD-19175 | biostudies-arrayexpress

MicroRNAs are important mediators of BMP-7 induced dendritic growth in sympathetic neurons

Project description:MicroRNA profiling of cultured sympathetic neurons from the superior cervical ganglia of E21 Sprague-Dawley rat pups following growth under control conditions or after treatment with BMP-7 at 50 ng/mL for 6 hours or 24 hours.

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Differential gene expression in lactating rats compared against age matched virgin controls

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Maternal allergic sensitization affects the T cell modulatory capacity of milk derived extracellular vesicles

Project description:Background: Human milk extracellular vesicles (EVs) affect various cell types in the gastrointestinal tract, including T cells, and play a role in the development of the newborn’s immune system by delivering specific molecular cargo to target cells. Although maternal allergic sensitization alters the composition of milk, it is unknown whether this impacts the function of milk EVs. Therefore, we analyzed the T cell modulatory capacity and compared the protein and miRNA cargo of EVs from milk of allergic and non-allergic mothers. Methods: EVs were isolated from human milk from allergic and non-allergic donors by differential centrifugation, density gradient floatation and size exclusion chromatography. Functional modulation of primary human CD4+ T cells by EVs was assessed in vitro. Proteomic analysis and small RNA sequencing was performed on milk EVs to evaluate protein and miRNA abundance and to identify cellular targets of this EV cargo in relevant T cell signaling pathways. Results: T cell proliferation, activation and cytokine production were suppressed in the presence of milk EVs. Remarkably, milk EVs from allergic mothers modulated T cell activation to a lesser extent than EVs from non-allergic mothers. Integrative multi-omics analysis identified EV cargo of which the cellular targets could be linked to T cell activation-associated processes. Conclusions: Milk EVs from non-allergic mothers are stronger inhibitors of T cell activation compared to milk EVs from allergic mothers. This altered functionality might be linked to small changes in modulation of certain T cell signaling pathways.

2022-10-30 | GSE216498 | GEO

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