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SnRNA-seq of Hexb-deficient brain cells upon microglia replacement

ABSTRACT: We used snRNA-sequencing to analzye NeuN-Olig2- thalamic brain cells derived from Hexb-deficient mice upon microglia replacement

ORGANISM(S): Mus musculus

PROVIDER: GSE300357 | GEO | 2025/06/24

REPOSITORIES: GEO

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snRNA-seq of Hexb-deficient brain cells

Project description:We used snRNA-sequencing to analzye all thalamic brain cells derived from Hexb-deficient and competent cells.

2025-06-24 | GSE300359 | GEO

snRNA-seq of Sandhoff disease brain cells

Project description:We used snRNA-sequencing to analzye thalamic brain nuclei (NeuN-;Olig2-) derived from Sandhoff disease patients and unaffected controls

2025-06-24 | GSE300356 | GEO

snRNA-seq of Hexb-deficient brain cells upon microglia replacement

Project description:snRNA-seq of Hexb-deficient brain cells upon microglia replacement

| PRJNA1280146 | ENA

bulk RNA-seq of Hexb-deficient microglia

Project description:We used bulk RNA-sequencing to analzye microglia derived from Hexb-deficient and competent cells.

2025-06-24 | GSE300355 | GEO

snRNA-seq of Hexb-deficient brain cells

Project description:snRNA-seq of Hexb-deficient brain cells

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RNA sequencing data of microglia isolated from brains of WT, Hexb-tdTomato, Hexb-CreERT2 and Hexb-KO mice. [Hexb-KO]

Project description:RNA sequencing of FACS sorted microglia isolated from brain tissue of WT, Hexb-tdTomato, Hexb-CreERT2 and Hexb-KO mice was performed to test for potential differences in gene expression caused by the knock-in of tdTomato and CreERT2 into the Hexb locus.

2020-05-25 | GSE148411 | GEO

RNA sequencing data of microglia isolated from brains of WT, Hexb-tdTomato, Hexb-CreERT2 and Hexb-KO mice. {Reporter]

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RNA sequencing data of microglia isolated from brains of WT, Hexb-tdTomato, Hexb-CreERT2 and Hexb-KO mice. [Cre]

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Single cell transcriptomics analysis of microglia from mouse models of CNS diseases

Project description:We used snRNA-sequencing to understand trancriptomic response of CNS cell nuclei after de-enrichment of NeuN+Olig2+ nuclei after fluorescence based sorting.

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Expression data of the thymus from 15weeks old Hexb-/- and Hexb+/- mice

Project description:Sandhoff disease (SD) is a lysosomal storage disorder characterized by the absence of β-hexosaminidase and storage of GM2 ganglioside and related glycolipids. We found the alterations in the thymus during the development of mild to severe progressive neurologic disease. To elucidate the molecular basis of thymic involution, we performed cDNA microarray analysis to identify the changes in gene expression that accompanied the involution of the thymus. 8018 probes were found to be relatively increased in the thymus of the Hexb-/- mice, an animal model for SD, compared with that of the Hexb+/- mice. On the other hand, the expression of 7604 probes was relatively decreased. The cohort of up-regulated sequences was dominated by genes that play a role in the immune response. In addition, some of these genes are expressed in macrophage lineages such as macrophage expressed gene 1, and colony stimulating factor 2 receptor beta 1. Th2 cytokines were mostly upregulated in the Hexb-/- mice, although Th1 cytokines did not show this increase. In addition, B cell related genes such as CD19, CXCL13 were increased, whereas the T cell-related genes were mostly decreased, in Hexb-/- mice compared with Hexb+/- mice.

2009-12-25 | GSE19641 | GEO

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