FDX1-mediated cuproptosis promotes cholestaic liver injury exacerbated by taurocholic acid

ABSTRACT: As the primary route for copper elimination, cholestasis raises questions about the role of copper in cholestatic liver injury and its specific molecular mechanisms. Our findings reveal that cholestasis-induced copper overload drives liver injury via taurocholic acid (TCA) -exacerbated and FDX1-mediated cuproptosis.

ORGANISM(S): Mus musculus

PROVIDER: GSE300382 | GEO | 2026/01/14

REPOSITORIES: GEO