Expression data comparing the effect of IKK2 KO on a KRAS mouse model

ABSTRACT: Given that the NF-κB pathway plays an important role in tumor development and that IKK2 is the seminal kinase responsible for NF-κB pathway activation, we were particularly interested in exploring the therapeutic potential of IKK2 inhibition in non-small cell lung cancers. We crossed IKK2fl/fl and KrasG12D mice so that we could simultaneously activate KrasG12D to initiate tumor formation and inactivate IKK2, upon transduction by Cre lentiviral vectors.

ORGANISM(S): Mus musculus

PROVIDER: GSE30049 | GEO | 2011/12/15

SECONDARY ACCESSION(S): PRJNA144073

REPOSITORIES: GEO