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Neuro-Glioblastoma Connectivity: Brain-Wide Mapping and Cholinergic Modulation of Tumor Progression

ABSTRACT: This study explores the effect of long-range cholinergic input on glioblastoma (GBM) progression based on systematically mapping neuron-glioma connectivity via monosynaptic rabies virus tracing. To address the mechanism of cholinergic and glutamate inputs lead to increased GBM cell proliferation, we examined transcriptomic changes in patient-derived GBM cells at both early (3h) and chronic (24h) time points following brief exposure to glutamate, Cev, or their combination.

ORGANISM(S): Homo sapiens

PROVIDER: GSE300506 | GEO | 2025/07/31

REPOSITORIES: GEO

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