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Exploring tumor dynamics and responses of prostate cancer to IL-27 based treatment combinations through biodynamic imaging and RNA sequencing analyses

ABSTRACT: We use Biodynamic imaging and transcriptomics to study the response of cells to various drugs applied ex-vivo to measure and correlate the intracellular motion as a biomarker of tumor samples therapies. Prostate Cancer has been used as a model in this study. The control and IL-27 treated tumors were exposed to chemo/immunotherapy drugs ex vivo and BDI was used to profile changes in the TME. The integration of these techniques will enable informed decision-making regarding combination treatment strategies for PCa.

ORGANISM(S): Mus musculus

PROVIDER: GSE300646 | GEO | 2025/12/09

REPOSITORIES: GEO

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