Ryder: Epigenome Normalization and Variable Feature Identification

ABSTRACT: Sequencing-based epigenomic profiling significantly advances our understanding of chromatin regulation, yet inherent technical variability complicates accurate cross-sample comparisons. We introduce Ryder, a flexible Python package leveraging stable internal reference regions to perform robust genome-wide normalization. Ryder effectively reduces technical artifacts, distinguishes biological signals, and identifies variable genomic regions across diverse assays, including DNase-seq, ATAC-seq, MNase-seq, and ChIP-seq, with or without spike-in controls.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE300647 | GEO | 2026/04/14

REPOSITORIES: GEO