Organoid modeling of lung branching morphogenesis and epithelial lineage specification [RNA-Seq]

ABSTRACT: In this study, multi-level branching lung organoids (BLOs) were generated from primary tip epithelial cells. Single-cell RNA sequencing demonstrated that BLOs comprise proximal airway and distal alveolar epithelial cell populations, faithfully modeling the developmental trajectory of distal lung epithelial lineages in vitro.

ORGANISM(S): Mus musculus

PROVIDER: GSE300722 | GEO | 2026/06/23

REPOSITORIES: GEO