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Clariom D Pico gene array of microdissected lipid droplet (LD)+ and LD- human GBM areas.

ABSTRACT: In this study, we aimed to elucidate the molecular underpinnings of metabolic adaptation in the stressed TME. LD accumulation has been well documented in glioblastoma (GBM), a prototypical high-grade brain malignancy characterized by severe acidosis, hypoxia, and metabolic heterogeneity. Unexpectedly, we observed a prominent enrichment of pathways related to glycocalyx remodeling in the LD-rich niche of patient tumors, particularly those involving CS biosynthesis and PG regulation. These findings prompted us to explore how glycan remodeling intersects with lipid metabolism in GBM and whether this interaction contributes to tumor stress adaptation. Our results highlight an acidosis-induced glycan program with potential as a metabolic vulnerability, offering new therapeutic avenues for targeting the lipid-stressed niche in aggressive tumors. We used microarrays to evaluate transcriptional signature realted lipid droplet (LD)+ and LD- regions of patient glioblastoma (GBM) sections.

ORGANISM(S): Homo sapiens

PROVIDER: GSE300758 | GEO | 2026/01/04

REPOSITORIES: GEO

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