Effect of FL-Fc-DM1 drug on gene expression of Molm-13 cells pretreated with cytarabine.

ABSTRACT: Cytarabine is one of the first line chemo drugs to treat acute myeloid leukemia (AML). However, cytarabine can induce AML cell cell cycle arrest at G0/G1 phase. These cell-cycle-arrested AML cells resist cytarabine, show a senescence-like phenotype or stem-cell like phenotype. To eliminate these cell-cycle arrested cells, we developed a FL-Fc-DM1 drug by conjugating FLT3 liangd Fc fusion protein and mertansine. We used the Molm-13 cells as a AML model. The total mRNA of Molm-13 cells treated with different drugs (cytarabine, FL-Fc-DM1) were sequenced.

ORGANISM(S): Homo sapiens

PROVIDER: GSE300904 | GEO | 2025/06/30

REPOSITORIES: GEO