Menin regulates YBX1 nuclear translocation to drive HKDC1 transcription and restrain glycolysis in pancreatic ductal adenocarcinoma

ABSTRACT: Menin suppresses glycolysis in PDAC by binding YBX1, promoting its nuclear import, and up-regulating HKDC1 transcription. RNA-seq on PL45 cells over-expressing Menin versus vector control identified 413 DEGs; key metabolic genes GLUT1 and LDHA were down-regulated, while HKDC1 was up-regulated. Findings highlight a Menin-YBX1-HKDC1 axis as a potential therapeutic target.

ORGANISM(S): Homo sapiens

PROVIDER: GSE301126 | GEO | 2025/09/03

REPOSITORIES: GEO