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SWAP70 Promotes Atherosclerosis via Endothelial CAV1 Nuclear Translocation [ATAC-seq]

ABSTRACT: Hemodynamic forces play a pivotal role in modulating endothelial function and contribute to the spatial distribution of atherosclerotic lesions. Here, we identify SWAP70 as a flow-sensitive gene whose chromatin accessibility is dynamically regulated by shear stress. Using ATAC-seq analysis of human endothelial cells exposed to static conditions, laminar shear stress (LSS), or oscillatory shear stress (OSS) for 72 hours, we observed that OSS markedly increased chromatin accessibility at the SWAP70 promoter compared to LSS. This enhanced accessibility under OSS suggests transcriptional activation of SWAP70 in response to disturbed flow. These findings indicate that SWAP70 may serve as a mechanosensitive regulator, epigenetically primed by atheroprone flow patterns to modulate endothelial inflammation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE301155 | GEO | 2026/01/08

REPOSITORIES: GEO

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Integrated Proteomics and Metabolomics Analysis Reveals Differential Lipid Metabolism in HUVEC under high and low shear stress

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