Ion Torrent RNA-sequencing of microdissected chemorefractory and chemosensitive high-grade serous ovarian cancer samples
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ABSTRACT: To identify miRNAs that are associated with intrinsic chemoresistance, we performed next-generation Ion Torrent miRNA-sequencing analysis on RNA isolated from microdissected chemo-refractory samples (i.e., tumors not responsive to initial chemotherapy) and microdissected chemo-sensitive samples (i.e., tumors with relapsed HGSC 6 months after the last cycle of chemotherapy) of treatment-naïve advanced high-grade serous ovarian cancer (HGSC). We identified an miRNA signature with a set of miRNAs and their variants that showed significant differential copy numbers in chemo-refractory samples compared to chemo-sensitive samples.
ORGANISM(S): Homo sapiens
PROVIDER: GSE301196 | GEO | 2026/03/18
REPOSITORIES: GEO
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