Distinct lung functional, histological and cell senescence signatures in the single vs repetitive bleomycin mouse model of idiopathic pulmonary fibrosis

ABSTRACT: To address the gap between acute bleomycin-induced fibrosis in mice and the chronic nature of human IPF, we performed RNA-seq on lung tissue from single-dose and repetitive bleomycin models of idiopathic pulmonary fibrosis (BLEO-IPF). We find that the repetitive BLEO-IPF model recapitulates the key features of progressive fibrosis and senescence, offering a relevant pre-clinical platform for studying chronic IPF pathology and evaluating anti-fibrotic interventions.

ORGANISM(S): Mus musculus

PROVIDER: GSE301216 | GEO | 2025/09/22

REPOSITORIES: GEO