Osteocyte-specific deletion of Gasdermin D drives osteoarthritis cartilage degeneration by promoting inflammation and remodeling in subchondral bone.

ABSTRACT: In osteoarthritis, we discovered that pyroptosis of osteocytes in the subchondral bone contributes to disease progression. Ongoing studies using knockout mouse models aim to elucidate the effects of inhibiting this pathological pathway on disease progression .

ORGANISM(S): Mus musculus

PROVIDER: GSE301329 | GEO | 2026/06/15

REPOSITORIES: GEO