Regulation of the transcriptome, miRNAs and alternative splicing in a FSGS zebrafish injury model

ABSTRACT: Focal Segmental Glomerulosclerosis (FSGS) is a severe kidney disorder with complex and not yet fully understood pathogenesis. To investigate the role of AS in FSGS, we used a well-established zebrafish model, which mimics key human FSGS features, including foot process effacement, matrix accumulation, podocyte detachment and parietal epithelial cell activation. We performed RNA sequencing of isolated glomeruli and whole larvae, followed by integrative bioinformatic analysis to identify AS events and regulatory miRNAs.

ORGANISM(S): Danio rerio

PROVIDER: GSE301334 | GEO | 2026/06/22

REPOSITORIES: GEO