B cell signature during inactive systemic lupus

ABSTRACT: Systemic lupus erythematosous (SLE) is an autoimmune disease with an important clinical and biological heterogeneity. B lymphocytes appear central to the development of SLE which is characterized by the production of a large variety of autoantibodies and hypergammaglobulinemia. In mice, immature B cells from spontaneous lupus prone animals are able to produce autoantibodies when transferred into immunodeficient mice, strongly suggesting the existence of intrinsic B cell defects during lupus. In order to approach these defects in humans, we compared the peripheral B cell transcriptomes of quiescent lupus patients to normal B cell transcriptomes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE30153 | GEO | 2011/06/23

SECONDARY ACCESSION(S): PRJNA143913

REPOSITORIES: GEO