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Effect of treating AKPS organoids with either single agent KRAS G12C inhibition, TEAD inhibiton or APC restoration, or dual and triple combination on gene expression.

ABSTRACT: We have previously shown that single agent treatment with either divarasib (KRAS G12Ci) or APC restoration, results in cell plasticity. Here, we aim to evaluate the effects on combination treatment and if gene expression changes can be enhanced with TEAD inhbiiton.

ORGANISM(S): Mus musculus

PROVIDER: GSE301568 | GEO | 2026/04/05

REPOSITORIES: GEO

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Effect of treating AKPS organoids with either single agent KRAS G12C inhibition or APC restoration, or combination on chromatin accessibility.

Project description:We show that single agent treatment with either divarasib (KRAS G12Ci) or APC restoration, results in cell plasticity.

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