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Gene expression analysis of mantle cell lymphoma (MCL) combined with laser microdissection

ABSTRACT: Wnt3 signaling pathway plays a central role in lymphomagenesis, and that specific mitotic regulators facilitate transformation into more aggressive forms.

ORGANISM(S): Homo sapiens

PROVIDER: GSE30189 | GEO | 2011/06/25

SECONDARY ACCESSION(S): PRJNA143977

REPOSITORIES: GEO

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Gene expression analysis of mantle cell lymphoma (MCL) combined with laser microdissection

Project description:Wnt3 signaling pathway plays a central role in lymphomagenesis, and that specific mitotic regulators facilitate transformation into more aggressive forms. For initiation, we compared the tumor cells of MCL in situ (n=4) with normal mantle zone B-lymphocytes (n=4), which were selected by laser microdissection.For transformation, we selected the overlapping genes differentially expressed between both cMCL (n=4) vs aMCL (n=5) and classical vs aggressive areas in iMCL (n=2).

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A defect of the INK4-Cdk4 checkpoint and c-myc collaborate in blastoid mantle cell lymphoma (MCL)-like lymphoma formation in mice

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Immunotoxin BL22 induces apoptosis in mantle cell lymphoma (MCL) cells dependent on Bcl-2 expression.

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Transcriptional responses of mantle cell lymphoma (MCL) lines to PKC inhibition

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