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Estrogen-like activity and dual roles in cell signaling of an Agaricus blazei Murrill mycelia-dikaryon extract

ABSTRACT: Comparing the expression profiles of the genes in response to 17b-estradiol (E2) and Agaricus blazei extract (ABE)

ORGANISM(S): Homo sapiens

PROVIDER: GSE30193 | GEO | 2014/01/01

SECONDARY ACCESSION(S): PRJNA143945

REPOSITORIES: GEO

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Estrogen-like activity and dual roles in cell signaling of an Agaricus blazei Murrill mycelia-dikaryon extract

Project description:Comparing the expression profiles of the genes in response to 17b-estradiol (E2) and Agaricus blazei extract (ABE) Two-condition experiment, E2- or ABE-treated vs. control cells. 2 to 3 biological replicates, independently grown and harvested. Two to three replicates per array.

2014-01-01 | E-GEOD-30193 | biostudies-arrayexpress

Pancreatic adenocarcinoma cell lines were treated with Agaricus blazei Murrill hot water extract (AbE).

Project description:Pancreatic cancer is one of the most aggressive human malignancies with 7.1% five-year survival rate due to late-stage diagnosis and lack of effective treatment. A novel active compound to be useful for treating pancreatic cancer is absolutely demanded. Agaricus blazei (A. blazei) Murrill has been shown to have an anti-cancer activity, however, its specific efficacy and underlying mechanism is poorly understood. Here, we demonstrated that A. blazei hot water extract (AbE) showed significant growth inhibition of cultured pancreatic cancer cells with less suppressive effect on the normal human pancreatic duct epithelial cells. The pancreatic cancer cells committed G0/G1 cell cycle arrest and caspase-dependent apoptosis. Moreover, we uncovered significant alterations of global gene expression in the pancreatic cancer cells by AbE treatment. Signature of alteration of gene expression indicated that AbE induced repression of genes associated with kinetochore function, spindle formation, centromere maintenance, and cyclins and cyclin dependent kinases, which were essential for cell cycle progression. The gene expression analysis also showed upregulation of proapoptotic genes. These results indicate that AbE could be useful for treatment of pancreatic cancer and a good candidate to isolate potent active compound for development of novel drug for pancreatic cancer.

2018-10-31 | GSE89396 | GEO

Estrogen-like activity and dual roles in cell signaling of brefeldin A

Project description:Comparing the expression profiles of the genes in response to 17b-estradiol (E2) and brefeldin A (BFA)

2014-01-01 | GSE33851 | GEO

Transcription profiling of human monocyte cell line treated with medicinal extract from Agaricus blazei Murill

Project description:The effect on gene expression of an extract from a medicinal mushroom (Agaricus blazei Murill)were compared with the effect of lipopolysaccharides (LPS). Both are potent immunomodulators. The study used a monocyte cell line.

2013-01-29 | E-BASE-1 | biostudies-arrayexpress

Estrogen-like activity and dual roles in cell signaling of brefeldin A

Project description:Comparing the expression profiles of the genes in response to 17b-estradiol (E2) and brefeldin A (BFA) Two-condition experiment, E2- or BFA-treated vs. control cells. Two biological replicates, independently grown and harvested. Two replicates per array.

2014-01-01 | E-GEOD-33851 | biostudies-arrayexpress

Estrogen-like activity and dual roles in cell signaling of an Agaricus blazei Murrill mycelia-dikaryon extract

Project description: Not available

| S-ECPF-GEOD-30193 | biostudies-other

Estrogen-like activity in cell signaling of capsaicinoids

Project description:Comparing the expression profiles of the genes in response to 17b-estradiol (E2) and capsaicinoids (capsaicin (CAP), dihydrocapsaicin (DHCAP), nordihydrocapsaicin (NDHCAP), nonivamide (NV))

2017-06-13 | GSE64155 | GEO

Estrogen-like activity in cell signaling of lignans

Project description:Comparing the expression profiles of the genes in response to 17b-estradiol (E2) and lignans (sesamin (SE), enterodiol (ED), enterolactone (EL), matairesinol (MR), pinoresinol (PR)).

2017-03-08 | GSE86565 | GEO

Effects on gene expression of a medicinal extract from Agaricus blazei in patients with hepatitis C infection

Project description:Extracts from the mushroom Agaricus blazei Murill (AbM) are used extensively as a non-prescription remedy against cancer and infections, including hepatitis. We previously demonstrated a potent immunomodulating effect of a particular preparation on monocytes in vitro, and a protective effect on bacterial infections in mice. Here we report the effect on gene expression in peripheral blood cells from four chronic hepatitis C patients, using global (29 k) oligo-based, single channel microarrays. The viral load was slightly, but not significantly, decreased after one week of AbM treatment. The cytokine genes most strongly induced in vitro were not induced in vivo. The more notable changes in mRNA levels related to genes involved in the G-protein coupled receptor signalling pathway, in cell cycling, and in transcriptional regulation. The results suggest that the β-glucans of the extract, which presumably are responsible for cytokine induction, did not readily enter the blood, while other components, such as substances proposed to have anticancer effects, were active in the blood. Keywords: experimental treatment, mushroom extract, hepatitis C infection

2006-02-20 | GSE3983 | GEO

Expression profiling of the genes responding to zearalenone and its analogues using estrogen-responsive genes.

Project description:Comparing the expression profiles of the genes in response to estrogen or 17b-estradiol (E2) and a mycotoxin, zearalenone (ZEA), and its analogues. Keywords: Gene expression profiling

2010-03-11 | GSE15249 | GEO

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