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IL-25-induced effector-memory ILC2s mediate small intestinal adaptation [ATAC-seq]

ABSTRACT: This study used bulk ATAC sequencing of either small intestinal ILC2s or Lgr5+ epithelial stem cells +50 days after an IL-25 regimen or PBS regimen in wild type (ILC2s) or Lgr5DTR-EGFP (epithelial stem cells) mice to study chromatin accessibility.

ORGANISM(S): Mus musculus

PROVIDER: GSE301998 | GEO | 2025/07/28

REPOSITORIES: GEO

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IL-25-induced effector-memory ILC2s mediate small intestinal adaptation [scRNA-Seq 2]

Project description:This study used single cell RNA sequencing of small intestinal ILC2s +50 days after an IL-25 regimen or PBS regimen in wild type and Il25-/- mice to study memory ILC2 gene signatures.

2025-07-28 | GSE301976 | GEO

IL-25-induced effector-memory ILC2s mediate small intestinal adaptation [scRNA-seq]

Project description:This study used single cell RNA sequencing of small intestinal epitheilal cells +50 days after an IL-25 regimen or PBS regimen in wild type mice to study long-term changes in gene expression by epitheilal cells.

2025-07-28 | GSE301999 | GEO

IL-25-induced effector-memory ILC2s mediate small intestinal adaptation [scRNA-Seq 1]

Project description:This study used single cell RNA sequencing of small intestinal ILC2s +60 days after helminth infection (Nippostrongylus brasiliensis-Nb. or Heligmosomoides polygyrus, Hp.) and in age matched naïve mice (Ctrl) to study memory ILC2 gene signatures after helminth infection.

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Differential activation of human ILC2s by IL-25 and IL-33

Project description:The epithelial cell derived cytokines IL-25 and IL-33 can both activate type 2 innate lymphoid cells (ILC2s). It is not known whether the actions of these cytokines on ILC2s are similar or divergent. To investigate this we performed in vitro culture of human ILC2s with a variety of cytokine combinations including IL-2, IL-7, IL-25 and IL-33. Transcriptome profiling of these different condtions allowed us to assess the impact on gene expression of the different treatments. The results show that IL-25 and IL-33 promote divergent gene expression programs indicating that differential expression of these cytokines can cause diverse ILC2 effector function.

2017-08-01 | GSE72433 | GEO

IL-25-induced effector-memory ILC2s mediate small intestinal adaptation [ATAC-seq]

Project description:IL-25-induced effector-memory ILC2s mediate small intestinal adaptation [ATAC-seq]

| PRJNA1288253 | ENA

IL-25-induced effector-memory ILC2s mediate small intestinal adaptation [scRNA-seq]

Project description:IL-25-induced effector-memory ILC2s mediate small intestinal adaptation [scRNA-seq]

| PRJNA1288260 | ENA

IL-25-induced effector-memory ILC2s mediate small intestinal adaptation [scRNA-Seq 1]

Project description:IL-25-induced effector-memory ILC2s mediate small intestinal adaptation [scRNA-Seq 1]

| PRJNA1287815 | ENA

IL-25-induced effector-memory ILC2s mediate small intestinal adaptation [scRNA-Seq 2]

Project description:IL-25-induced effector-memory ILC2s mediate small intestinal adaptation [scRNA-Seq 2]

| PRJNA1287816 | ENA

Expression data from naive, effector and memory-like ILC2s isolated from mouse lungs and those from effector and memory-like ILC2s isolated from mediastinal lymph node

Project description:Group 2 innate lymphoid cells (ILC2s) in the lung are stimulated by inhaled allergens. ILC2s do not directly recognize allergens but they are stimulated by cytokines including interleukin (IL)-33 released by damaged epithelium.Lung ILC2s, upon stimulation, produce T helper 2 cell-type cytokines inducing T cell independent allergic lung inflammation. We now report that lung ILC2s, upon activation by an allergen or IL-33, acquire the properties of memory cells. The activated ILC2s initially proliferate and secrete cytokines, followed by a contraction phase as they stop producing cytokines. Nevertheless, some persist long after the resolution of the inflammation and acquire intrinsic capacities to react to unrelated allergens more vigorously than naÃ¯ve ILC2s, thus mediating a severe allergic lung inflammation. Gene expression profiles of the previously activated ILC2s show a gene signature of memory T cells. These antigen non-specific memory ILC2s may explain why asthma patients are often sensitized to multiple allergens. ILC2s were isolated from mouse lungs from naive and IL-33 injected mice 4 days, 14 days and 4 months after the initial treatment. RNA was extracted from those ILC2 populations and analyzed for gene expression profiles. RNA was also extracted from ILC2s isolated from lung draining mediastinal lymph node (mLN) 4 days and 14 days after IL-33 treatment.

2016-06-30 | E-GEOD-81700 | biostudies-arrayexpress

Analysis of difference in transcriptome of ILC2s derived from WT C57BL/6 and RAG1-/- mice

Project description:Purpose: To analyze the transcriptome difference of ILC2s isoalted from WT and RAG-/- mice under inflammaed condition Method: Lung ILC2s from mice chronically challenged with papain (40 µg/20 µl PBS, 6 subsequest papain challenges, day 0, 1, 2, 13, 14, and 15)

2023-01-11 | GSE166779 | GEO

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