SRRM4 knockout helps the human mesenchymal stem cell line to intrude into decellularized bone

ABSTRACT: Analysis of the human bone marrow microenvironment requires an in vivo model that reflects this microenvironment. We introduced a human bone marrow mesenchymal stem cell (MSC) line into decellularized bone. Using the CRISPR Knock Out library, we identified serine/arginine repetitive matrix 4 knockout in an MSC cell line, as a candidate factor for bone intruding, which may be applied to the analysis of hematological diseases such as myelodysplastic neoplasm.

ORGANISM(S): Homo sapiens

PROVIDER: GSE302358 | GEO | 2025/07/16

REPOSITORIES: GEO