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Deletion 9p drives B-cell leukemia by the concomitant loss of Pax5 and Cd72

ABSTRACT: We used microarrays to analyze gene expression changes in preleukemic cells from Cd72+/-;Pax5+/-, Pax5+/- and WT mice. The oncogenic role of 9p deletion in B-ALL has remained elusive since its discovery more than 40 years ago. We combined genomic analysis and functional models to show that the co-deletion of two contiguous genes, Pax5 and Cd72, confers gain in malignancy.

ORGANISM(S): Mus musculus

PROVIDER: GSE302482 | GEO | 2026/02/09

REPOSITORIES: GEO

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