Oncolytic virus therapy mobilizes tumor-resident CD4+ bystander T cells to restore systemic anti-microbial immunity

ABSTRACT: The library preparation for single-cell RNA sequencing (scRNA-seq) using the BD Rhapsody platform to study SM CD4+ T cells in lung and spleen when undergoing OV-BYTE treatment. Here, we further demonstrate that OV-BYTE delivered dual defense against tumorigenesis and pathogen infections in pre-clinical models. This study gives a transcriptome profiles of SM CD4+ T cells in lung and spleen with administration of OV-BYTE treatment.

ORGANISM(S): Mus musculus

PROVIDER: GSE302621 | GEO | 2025/08/06

REPOSITORIES: GEO