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Transcriptomic profiling of primary mediastinal liposarcoma

ABSTRACT: Primary mediastinal liposarcoma (MLPS) is an extremely rare tumor with unclear molecular biology. We conducted RNA sequencing in five cases of MLPS and compared gene expression between dedifferentiated liposarcoma (DDLPS) and well-differentiated liposarcoma (WDLPS). Enrichment analyses and immune cell deconvolution revealed that DDLPS showed features of dedifferentiation, cell cycle activation, Wnt signaling, and immune-cold status. This dataset provides the first transcriptomic landscape of primary MLPS and offers insight into potential therapeutic targets.

ORGANISM(S): Homo sapiens

PROVIDER: GSE302769 | GEO | 2025/07/16

REPOSITORIES: GEO

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