DMSO control and DZNep treated MOLM-14 cells

ABSTRACT: We demonstrated that 3-Deazaneplanocin A (DZNep), a histone methyltransferase inhibitor, induce robust apoptosis in AML cells through increased ROS production and ER stress. We identified a core gene signature including TXNIP, a major redox control molecule which is crucial in DZNep-induced apoptosis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE30315 | GEO | 2011/07/01

SECONDARY ACCESSION(S): PRJNA143569

REPOSITORIES: GEO