Genomics

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Anthracyclines induce global changes in chromatin accessibility in cardiomyocytes that overlap with cardiovascular disease loci


ABSTRACT: We performed chromatin immunoprecipitation followed by sequencing (ChIP-seq) in human iPSC-derived cardiomyocytes to map genome-wide binding sites of TOP2B. Libraries were prepared from ChIP and matched input DNA, sequenced using 40 bp paired-end reads. After quality control and alignment to the human reference genome (GRCh38), high-confidence reads were filtered and duplicate reads removed. Peak calling using MACS2 in broad mode identified 5,410 enriched genomic regions, enabling investigation of TOP2B-associated regulatory elements in human cardiomyocytes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE303207 | GEO | 2025/09/15

REPOSITORIES: GEO

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