Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Spatial transcriptomics of the normal and cytomegalovirus-infected guinea pig placenta

ABSTRACT: Cytomegalovirus infection can disrupt placental development and function either by directly infecting placental cells or by eliciting a pathogenic immune response. Guinea pig cytomegalovirus (GPCMV) infection after mid-gestation causes transcriptional changes indicative of immune activation and focal infections at the base of the main placenta. In this study, we used spatial transcriptomics to quantify host and viral gene expression at the maternal-fetal interface at near single-cell resolution.

ORGANISM(S): Cavia porcellus

PROVIDER: GSE303764 | GEO | 2025/08/03

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Transcriptome profiling of guinea pig cytomegalovirus infected cells

Project description:We report the transcriptome profiles of guinea pig cytomegalovirus (Caviid betaherpesvirus 2 ; GPCMV) infected and uninfected cells. RNA was harvested at an early time post-infection. Data sets from a lung fibroblast cell line (JH4), primary amnion derived cells (1° AECs), and HPV16 E6/E7-transduced amniotic epithelial cells (AECD) is shared.

2020-06-17 | GSE134239 | GEO

Transcriptome profiling of cytomegalovirus-infected guinea pig placenta.

Project description:Transcriptome profiling of cytomegalovirus-infected guinea pig placenta.

| PRJNA716319 | ENA

Transcriptome profiling of cytomegalovirus-infected guinea pig placenta.

Project description:We report the transcriptomes of gunea pig cytomegalovirus (GPCMV)- and mock-infected placentas.

2021-05-25 | GSE169358 | GEO

Spatial transcriptomics of the normal and cytomegalovirus-infected guinea pig placenta

Project description:Spatial transcriptomics of the normal and cytomegalovirus-infected guinea pig placenta

| PRJNA1297636 | ENA

Transcriptome profiling of guinea pig cytomegalovirus infected cells

Project description:Transcriptome profiling of guinea pig cytomegalovirus infected cells

| PRJNA554444 | ENA

The Guinea Pig Serves as an Alternative Model to Study Human Preimplantation Development

Project description:Preimplantation development is a pivotal phase in human embryogenesis, establishing fundamental lineages and being crucial for overall health. Ethical constraints with human embryos necessitate a model organism, and the guinea pig, with its physiological similarities to humans, emerges as a valuable alternative. This rodent mirrors human preimplantation timing, placental features, and fetal development. Importantly, it serves as a model for studying long-term consequences of prenatal insults. Comparative studies across species, including guinea pigs, are essential for unraveling pluripotency mechanisms, offering insights into conserved and divergent aspects and understanding evolutionary adaptations. Addressing the lack of guinea pig embryonic transcriptomic data, this research employs single-cell RNA sequencing, immunofluorescence, and epigenetic analyses to explore gene expression, metabolic requirements, and X-chromosome inactivation dynamics. The study advances our understanding of early embryogenesis, emphasizing the guinea pig's relevance as a model for developmental and pluripotency research.

2025-01-06 | GSE253670 | GEO

Repeat tick exposure elicits distinct immune responses in guinea pigs and mice [guinea pig]

Project description:RNA-seq gene expression analysis of guinea pig and mouse skin after tick bites

2023-04-20 | GSE148967 | GEO

Transcriptomics analysis of guinea pig heart, fetus to adult progression

Project description:We report the outcomes of next-generation sequencing (RNA-Seq) of guinea pig (Cavia porcellus) heart tissue and compare relative transcript abundances between fetus and adult.

2018-05-01 | GSE108420 | GEO

RNA-seq of ten guinea pig tissues from breeders and non-breeders

Project description:Comparison of gene expression level by Illumina sequencing of ten different guinea pig tissue from breeders and non-breeders.

2018-06-14 | GSE98653 | GEO

Guinea pig myopia model ocular posterior pole

Project description:Proteomic analyses of the ocular posterior pole tissues at 6 weeks after induction of form-deprived myopia and lens-induced myopia models in guinea pigs.

2022-11-01 | PXD037872 |

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data