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Rps19bp1 cKO Xmlc2Cre E11.5 mouse heart RNAseq

ABSTRACT: This study investigates the transcriptomic consequences of cardiomyocyte-specific deletion of Rps19bp1 during mouse embryonic development. Rps19bp1 encodes AROS (Active Regulator of SIRT1), a known negative regulator of p53. To understand its role in cardiac development and cell cycle regulation, we performed RNA sequencing (RNA-seq) on ventricular heart tissues from E11.5 embryos of Rps19bp1 conditional knockout (cKO) mice and littermate controls. The data reveal widespread gene expression changes and activation of p53 signaling in Rps19bp1-deficient hearts, providing mechanistic insights into how Rps19bp1 modulates cardiomyocyte proliferation and embryonic heart morphogenesis.

ORGANISM(S): Mus musculus

PROVIDER: GSE303775 | GEO | 2026/02/18

REPOSITORIES: GEO

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