Halofuginone exerts broad-spectrum cytotoxic effects by regulating p-eIF2α-S100A8/A9-calcium signaling, inhibiting global protein synthesis, and reversing the resistance of idarubicin in acute myeloid leukemia [RNA-Seq]

ABSTRACT: Alkaloid febrifugine., an herbal medicine in China, is prescribed routinely for malaria treatment. Halofuginone (HF), a natural product isolated from alkaloid febrifugine, exhibits anti-tumor and anti-inflammatory ability. Aim of the study: Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy with low overall survival (OS). Resistance to chemotherapeutic drugs such as idarubicin (IDA) results in treatment failure. This study investigated the role of HF in anti-AML ability and in overcoming IDA resistance in AML cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE303946 | GEO | 2026/01/27

REPOSITORIES: GEO