Transcriptomics

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Single cell RNA sequencing of post-radiation mouse jejunum with or without DIZE


ABSTRACT: In a radiation mass casualty event, exposed populations will suffer dose-dependent toxicity to multiple-organ systems. Although several therapies are FDA-approved for treatment of the hematopoietic acute radiation syndrome (H-ARS), there are no FDA-approved medical countermeasures (MCM) for either acute gastrointestinal injury (GI) or late multi-organ toxicities known as the delayed effects of acute radiation exposure (DEARE). Prior data suggest activation of the alternative renin angiotensin (RAS) enzyme angiotensin-converting enzyme 2 (ACE2) has therapeutic potential for mitigating multi-organ radiation injury, including GI acute radiation syndrome (GI-ARS). Here, we evaluated whether pharmacologic activation of ACE2 mitigates GI-ARS in rodent models and protects against DEARE in GI-ARS survivors.

ORGANISM(S): Mus musculus

PROVIDER: GSE303960 | GEO | 2025/08/04

REPOSITORIES: GEO

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