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Identification of SOK1-dependent transcriptome changes under anaerobic conditions in the yeast Candida albicans

ABSTRACT: Dietary components influence microbial composition in the digestive tract. Although often viewed as energy sources, dietary components are likely to shape microbial determinants of intestinal colonization beyond metabolism. Here, we report that a dietary long-chain fatty acid enhances the yeast Candida albicans colonization of the murine gut partly by eliciting modifications to the fungal cell surface. Mice fed an oleic acid-rich diet were readily colonized by C. albicans and exhibited higher fungal load in feces compared to rodents fed an isocaloric control diet. Surprisingly, β-oxidation, a catabolic process to break down fatty acids for energy production, was dispensable for C. albicans to colonize the high-oleic acid diet-fed mice. We identified SOK1 as an oleic acid-induced kinase. RNA-Seq was employed to identify SOK1-dependent transcriptome changes. We found that SOK1 influences multiple cellular functions and components in C. albicans, including oxidoreductase activity, metabolism, and cell periphery.

ORGANISM(S): Candida albicans

PROVIDER: GSE303965 | GEO | 2025/08/13

REPOSITORIES: GEO

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Identification of SOK1-dependent transcriptome changes under anaerobic conditions in the yeast Candida albicans

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