Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

TRNA dosage regulates lineage plasticity and therapy resistance in prostate cancer through codon bias

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE304469 | GEO | 2026/08/26

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

tRNA dosage regulates lineage plasticity and therapy resistance in prostate cancer through codon bias [Polysome-seq]

Project description:Lineage plasticity underlies therapeutic resistance in cancer, yet the translational mechanisms enabling this phenotypic flexibility remain largely unknown. Using prostate cancer as a paradigm of lineage dependence, we performed unbiased small RNA sequencing and identified tRNAArg(UCU)-1 as a regulator of lineage transitions and therapy resistance. tRNAArg(UCU)-1 is both necessary and sufficient to reprogram lineage dependence which can be tuned to restore sensitivity to androgen receptor-targeted therapies. We identify TARDBP and ZSCAN29 as DNA-binding proteins that directly engage the genomic locus of tRNAArg(UCU)-1 to regulate its expression revealing the importance of non-canonical tRNA-specific gene regulation. Mechanistically, tRNAArg(UCU)-1 controls a translational program centered on SWI/SNF chromatin remodelers, which are necessary to maintain lineage fidelity. In patients, tRNAArg(UCU)-1 is downregulated in neuroendocrine prostate cancer and its loss is associated with accelerated metastasis and poor survival. These findings uncover a previously unrecognized tRNA-specific regulatory axis that links codon biology to lineage dependence and therapy resistance in prostate cancer.

2026-08-26 | GSE301566 | GEO

tRNA dosage regulates lineage plasticity and therapy resistance in prostate cancer through codon bias [msr-seq]

2026-08-26 | GSE304468 | GEO

tRNA dosage regulates lineage plasticity and therapy resistance in prostate cancer through codon bias [RNA-seq]

2026-08-26 | GSE336635 | GEO

tRNA dosage regulates lineage plasticity and therapy resistance in prostate cancer through codon bias [CUT&Run]

2026-08-26 | GSE336632 | GEO

tRNA dosage regulates lineage plasticity and therapy resistance in prostate cancer through codon bias

Project description:tRNA dosage regulates lineage plasticity and therapy resistance in prostate cancer through codon bias

| PRJNA1301343 | ENA

tRNA dosage regulates lineage plasticity and therapy resistance in prostate cancer through codon bias [CUT&Run]

Project description:tRNA dosage regulates lineage plasticity and therapy resistance in prostate cancer through codon bias [CUT&Run]