Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mitochondrial metabolism and signaling direct dendritic cell function in antitumor immunity [microarray3]

ABSTRACT: Transcriptional dissection of intratumoral cDC1s

ORGANISM(S): Mus musculus

PROVIDER: GSE304510 | GEO | 2026/01/26

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Mitochondrial metabolism and signaling direct dendritic cell function in antitumor immunity [microarray1]

Project description:Transcriptional dissection of cDC1s with polarized mitochondria or cDC1s with depolarized mitochondria

2026-01-26 | GSE285156 | GEO

Mitochondrial metabolism and signaling direct dendritic cell function in antitumor immunity [microarray2]

Project description:Transcriptional dissection of splenic WT and OPA1-deficient cDC1s

2026-01-26 | GSE285155 | GEO

Mitochondrial metabolism and signaling direct dendritic cell function in antitumor immunity [ATAC-seq2]

Project description:ATAC-seq profiling of intratumoral cDC1s

2026-01-26 | GSE304687 | GEO

Mitochondrial metabolism and signaling direct dendritic cell function in antitumor immunity

Project description:This SuperSeries is composed of the SubSeries listed below.

2026-01-21 | GSE285346 | GEO

Mitochondrial metabolism and signaling direct dendritic cell function in antitumor immunity

Project description:Mitochondrial metabolism and signaling direct dendritic cell function in antitumor immunity

| PRJNA1203201 | ENA

Mitochondrial metabolism and signaling direct dendritic cell function in antitumor immunity [microarray3]

Project description:Mitochondrial metabolism and signaling direct dendritic cell function in antitumor immunity [microarray3]

| PRJNA1301402 | ENA

Mitochondrial metabolism and signaling direct dendritic cell function in antitumor immunity [microarray2]

Project description:Mitochondrial metabolism and signaling direct dendritic cell function in antitumor immunity [microarray2]

| PRJNA1201316 | ENA

Mitochondrial metabolism and signaling direct dendritic cell function in antitumor immunity [microarray1]

Project description:Mitochondrial metabolism and signaling direct dendritic cell function in antitumor immunity [microarray1]

| PRJNA1201318 | ENA

Mitochondrial metabolism and signaling direct dendritic cell function in antitumor immunity [ATAC-seq2]

Project description:Mitochondrial metabolism and signaling direct dendritic cell function in antitumor immunity [ATAC-seq2]

| PRJNA1302328 | ENA

An NF-κB/IRF1 axis programs cDC1 to drive antitumor immunity

Project description:Conventional type 1 dendritic cells (cDC1s) are critical for anti-tumor immunity. They acquire antigens from dying tumor cells and cross-present them to CD8+ T cells, promoting the expansion of tumor-specific cytotoxic T cells. However, the signaling pathways that govern the anti -tumor functions of cDC1s are poorly understood. We mapped the molecular pathways regulating intratumoral cDC1 maturation using single cell RNA sequencing. We identified NF κB and IFN pathways as being highly enriched in a subset of functionally mature cDC1s. The specific targeting of NF-κB or IFN pathways in cDC1s prevented the recruitment and activation of CD8+ T cells and the control of tumor growth. We identified an NF-κB-dependent IFN-γ-regulated gene network in cDC1s, including cytokines and chemokines specialized in the recruitment and activation of cytotoxic T cells. We used single cell transcriptomes to map the trajectory of intra-tumoral cDC1 maturation which revealed the dynamic reprogramming of tumor-infiltrating cDC1s by NF-κB and IFN signaling pathways. This maturation process was perturbed by specific inactivation of either NF-κB or IRF1 in cDC1s, resulting in impaired expression of IFN-γ-responsive genes and consequently a failure to efficiently recruit and activate anti-tumoral CD8+ T cells. Finally, we demonstrate the relevance of these findings to cancer patients, showing that activation of the NF-κB/IRF1 axis in association with cDC1s is linked with improved clinical outcome. The NF-κB/IRF1 axis in cDC1s may therefore represent an important focal point for the development new diagnostic and therapeutic approaches to improve cancer immunotherapy.

2021-08-16 | GSE171870 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data