Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ASNA1 CKO with XMCL-CRE+ E14.5 mouse heart RNAseq

ABSTRACT: ASNA1 (also known as TRC40) is a key component of the tail-anchored (TA) protein targeting pathway. To investigate its role in the heart, we generated cardiomyocyte-specific ASNA1 conditional knockout (ASNA1 CKO) mice. RNA-seq analysis was performed on E14.5 embryonic heart to identify transcriptional changes caused by ASNA1 deficiency. Our results reveal that ASNA1 is essential for maintaining the stability of TA proteins and regulating vesicular transport in cardiomyocytes, which are critical for normal cardiac development and function.

ORGANISM(S): Mus musculus

PROVIDER: GSE304685 | GEO | 2025/08/10

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Transcriptional profiling of E14.5 control and Tbr2 fl/fl;Foxg1::Cre cortices

Project description:The abscence of TBR2 gene in human leads to microcephaly. This condition is mimicked by the specific ablation of the murine gene in developing cerebral cortex. Herein we compared gene expression in control and Tbr2 cKO in E14.5 cerebral cortices. This approach represents a useful tool to identify the molecular mechanisms at the basis of the phenotype.

2016-09-08 | GSE63619 | GEO

Transcriptional profiling of E14.5 control and Tbr2 fl/fl;Foxg1::Cre cortices

2016-09-08 | E-GEOD-63619 | biostudies-arrayexpress

Transcripts identified by microarray analysis that were deregulated in E14.5 Tbx18(cre/+);Rbpj(fl/fl) (Rbpj-cKO) ureters

Project description:Evaluation of the transcriptional changes in E14.5 ureters upon loss of Rbpj in the ureteric mesenchyme.

2022-01-04 | GSE169661 | GEO

Tandem mass tag proteomics analysis of protein expression in different mouse brains at E14.5 or P21

Project description:To investigate the potential function of UBAP1 in brain development, we conducted a global proteomics study in E14.5 Ubap1 ctrl and Nes-cKO mouse brain.

2024-01-19 | PXD048729 |

Ribosome-bound Get4/5 facilitate the capture of tail anchored proteins by Sgt2 in yeast

Project description:The guided entry of tail-anchored proteins (GET) pathway assists in the proper delivery of tail-anchored (TA) proteins to the ER. Here we uncover how the yeast GET pathway components Get4/5 mediate capture of TA proteins by Sgt2, which interacts with TA sequences and hands them over to the targeting component Get3. Get4/5 binds directly and with high affinity to ribosomes, positions Sgt2 close to the ribosomal tunnel exit, and facilitates the capture of TA proteins by Sgt2. The contact sites of Get4/5 on the ribosome overlap with those of SRP, the factor mediating cotranslational ER-targeting of proteins containing internal TM domains. Exposure of nascent, internal TM domains at the tunnel exit induces high-affinity ribosome-binding of SRP, which in turn prevents ribosome-binding of Get4/5. In this way, the position of TM domains within nascent ER-targeted proteins mediates partitioning into either the GET or SRP pathway directly at the ribosomal tunnel exit.

2020-12-18 | GSE151664 | GEO

Transcripts identified by microarray analysis that were deregulated in E14.5 Tbx18(cre/+) Rbpj(fl/fl) (Rbpj-cKO) ureters

Project description:Transcripts identified by microarray analysis that were deregulated in E14.5 Tbx18(cre/+) Rbpj(fl/fl) (Rbpj-cKO) ureters

| PRJNA717281 | ENA

Next Generation Sequencing of Loxp (Rxratm1Krc/J,Rxra loxP), Hetero(Nex-cre;Rxratm1Krc/J,Rxra cKO-Het) and cKO (Nex-cre;Rxratm1Krc/J,Rxra cKO) mouse Transcriptomes

Project description:When compared with Loxp, both Hetero and cKO mice showed reduced expression of immediate early genes

2019-09-04 | GSE136788 | GEO

RNAseq analysis of Chrnb4-cre driven Dicer conditional knockout (Dicer CKO) whole retinas

Project description:We have shown that Chrnb4-cre; Dicerflox/flox retinas (Dicer CKO) display a cone dystrophy by postnatal day P21, independent of rod degeneration. To elucidate which gene pathways were affected by Dicer loss, RNA sequencing was performed in whole neural retinas of P21 control and Dicer CKO mice. This experiment aims to identify which genes were differentially expressed between Dicer conditional knockout and control mice.

2019-01-14 | E-MTAB-6133 | biostudies-arrayexpress

miRNAseq analysis of Chrnb4-cre driven Dicer conditional knockout (Dicer CKO) whole retinas

Project description:We have shown that Chrnb4-cre; Dicerflox/flox retinas (Dicer CKO) display a cone dystrophy by postnatal day P21, independent of rod degeneration. To elucidate which miRNAs were involved in such phenotype, miRNA sequencing was performed in whole retinas of P21 and 3.5 month old control and Dicer CKO mice. This experiment aims to identify which miRNAs were differentially expressed in Dicer conditional knockout mice when compared to control mice.

2019-01-14 | E-MTAB-6132 | biostudies-arrayexpress

Transcriptome sequencing of E14.5 fetal liver erythroblast stage 1 cells in WT and LDB1 cKO mice

Project description:Transcriptome sequencing of E14.5 fetal liver erythroblast stage 1 cells in WT and LDB1 cKO mice

| PRJNA1040743 | ENA