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Characterization of WDR5 WIN-site Inhibition in Two Glioblastoma Cancer Stem Cell Models using Bulk RNAseq

ABSTRACT: WDR5 inhibitors have been implicated as a therapeutic vulnerability in glioblastoma cancer stem cells (CSCs). We tested the transcriptional effects of two different WDR5 WIN-site inhibitors, the dihydroisoquinoline C16 and the triazole C3TD078, in two CSC models (L0 and DI318) by bulk RNAseq.These data are associated with Coker et al., "Development and Characterization of Triazole-Based WDR5 Inhibitors for the Treatment of Glioblastoma," bioRxiv, 2025, https://doi.org/10.1101/2025.07.29.667410.

ORGANISM(S): Homo sapiens

PROVIDER: GSE304999 | GEO | 2025/08/15

REPOSITORIES: GEO

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