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Toll-like Receptor 4 Induces Trained Innate Immune Tolerance in the Heart in a Model of Stress-induced Cardiomyopathy [Multiome]

ABSTRACT: This study aimed to determine the mechanism by which TLR4 activation establishes cardiac protection in mice subjected to isoproterenol-induced cardiac injury. We performed Multiome sequencing to determine if this was set up through epigenetic means, which would suggest a mechanism consistent with trained innate immune tolerance.

ORGANISM(S): Mus musculus

PROVIDER: GSE305273 | GEO | 2025/09/22

REPOSITORIES: GEO

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