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GPR35+ tumor-associated neutrophils promote tumor growth in hepatocellular carcinoma.

ABSTRACT: Bulk RNA-seq profiling of tumor-associated neutrophils from Hepa1-6 mouse hepatocellular carcinoma (HCC) models. Neutrophils were isolated from mice HCC tissues and classified as GPR35+ or GPR35- subsets (n=3 per group). Differential expression analysis revealed significant upregulation of MAPK signaling pathway and pathways associated with neutrophil migration and cytokines production in GPR35+ neutrophils. These data support the pro-tumorigenic role of GPR35+ neutrophils in HCC.

ORGANISM(S): Mus musculus

PROVIDER: GSE305407 | GEO | 2026/04/05

REPOSITORIES: GEO

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GPR35+ tumor-associated neutrophils promote tumor growth in hepatocellular carcinoma.

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