An epigenetic basis for sustained inflammatory epithelial progenitor cell states in Crohn’s disease

ABSTRACT: Defining consequential differences in intestinal epithelial stem cells in healthy humans versus those with inflammatory bowel disease (Crohn’s disease (CD) and ulcerative colitis) is essential for the development of therapies to restore the epithelial barrier and maintain its fidelity post-injury. Our study objective was to define transcriptomic, epigenomic, and functional divergence between healthy and CD epithelium.

ORGANISM(S): Homo sapiens

PROVIDER: GSE305528 | GEO | 2025/12/31

REPOSITORIES: GEO