M6A epitranscriptome regulates axonogenesis and reprogramming of retinal ganglion cells [RNA-seq]

ABSTRACT: induced retinal ganglion cells (iRGCs) is an excellent system to generate RGC-like neurons for translational and theoretical studies. N6-methyladenosine (m6A) is the most prevalent internal modification in mRNAs. Using this iRGC system, we demonstrated that Mettl3, the core component of the m6A-methyltransferase complex, promotes iRGC axon development and the final iRGC reprogramming outcome.

ORGANISM(S): Mus musculus

PROVIDER: GSE305554 | GEO | 2026/02/24

REPOSITORIES: GEO