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ProCTLA-4 in anti-tumor immunity

ABSTRACT: We developed a prodrug of the anti-CTLA4 antibody, named ProCTLA-4. ProCTLA-4 elicits anti-tumor immune responses with reduced toxicity compared to current CTLA4 blockade therapies. Moreover, compared to currently used Probody Therapeutics targeting CTLA-4, ProCTLA-4 offers significant advantages for enhanced efficacy. Thus, our design establishes an alternative paradigm for antibody therapeutics that enables reduction of irAEs while simultaneously increasing therapeutic efficacy.

ORGANISM(S): Mus musculus

PROVIDER: GSE305582 | GEO | 2025/08/20

REPOSITORIES: GEO

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| phs001257 | dbGaP

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