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Gene Expression Analysis of Host Innate Immune Responses in the Brain and Spinal cord following Lethal CVS-11 Infection in Mice

ABSTRACT: The microarray and advanced pathway analysis of mice caused a paralysis in a fatal infection of a highly pathogenic CVS-11 was performed for the understanding of the detail gene networks and biological functions of inflammatory response and the related genes of innate immunity and apoptosis.

ORGANISM(S): Mus musculus

PROVIDER: GSE30577 | GEO | 2011/12/01

SECONDARY ACCESSION(S): PRJNA144645

REPOSITORIES: GEO

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Gene Expression Analysis of Host Innate Immune Responses in the Brain and Spinal cord following Lethal CVS-11 Infection in Mice

Project description:The microarray and advanced pathway analysis of mice caused a paralysis in a fatal infection of a highly pathogenic CVS-11 was performed for the understanding of the detail gene networks and biological functions of inflammatory response and the related genes of innate immunity and apoptosis. Brain Samples: Six female C57BL/6J mice aged six weeks old were inoculated 1E+7 focus-forming units (FFU) of CVS-11 propagated in MNA cells into the left hind limb, intramuscularly. On the other hand, MEM was inoculated into 6 negative control mice in a similar way. Each mice were sacrificed to collect their brains at days 7 postinoculation (dpi). Six mice were used for the analysis of microarray. The six of mock mice were also sacrificed at 7 dpi for the microarray analysis. Spinalcord Samples: Six female C57BL/6J mice aged six weeks old were inoculated 1E+7 focus-forming units (FFU) of CVS-11 propagated in MNA cells into the left hind limb, intramuscularly. On the other hand, MEM was inoculated into 6 negative control mice in a similar way. Each mice were sacrificed to collect their spinal cords at days 7 postinoculation (dpi). Six mice were used for the analysis of microarray. The six of mock mice were also sacrificed at 7 dpi for the microarray analysis.

2011-12-01 | E-GEOD-30577 | biostudies-arrayexpress

Gene Expression Analysis of Host Innate Immune Responses in the Central Nervous System following Lethal CVS-11 Infection in Mice

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Project description:In this study, we aimed to adopt the transcriptome sequencing technology to obtain the different changes of transcriptome profiles after infecting with CVS in human neuroblastoma cell line SH-SY5Y. And then, through systematic bioinformatics analysis, we hope to find useful clues for the pathogenesis of Rabies.

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Project description:Genome wide DNA methylation profiling of normal and trisomic placentas, and maternal blood cell DNA. The aim of this study was to search for methylation differences between maternal and fetal(placenta) cell free DNA, and between normal and trisomic placentas for an optimized methylation based noninvasive prenatal diagnosis of fetal chromosomal aberations. The Illumina Infinium 450k Human DNA methylation Beadchip was used to obtain DNA methylation profiles across approximately 450,000 CpGs in DNA samples from Chorionic villus samples(CVS) and DNA samples from whole blood. Samples included 12 Maternal blood cell samples from normal pregnancies, 12 normal CVS, 12 Trisomy 21 CVS, 12 trisomy 18 CVS and 6 trisomy 13 CVS samples.

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Expression data from the spinal cord of wild-type C57Bl/6 mice

Project description:The spinal cords of mice submitted to aortic cross-clamping for 7.5 minutes present with gray matter damage and central cord edema. 60% of mice subsequently experience hindlimb and tail paralysis. We used microarrays to detail the global programme of gene expression following aotic cross-clamping, in order to identify genes that could be responsible for edema and paralysis. RNAs extracted from the rostral (above T6) and caudal (below T6) part of the spinal cords of wild-type mice 24 and 48 hours following aortic cross-clamping were used for hybridization on Affymetrix microarrays. Mice submitted to sham surgery were used as controls.

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Project description:4 chorionic villus sampling specimens in pregnancies destined for preeclampsia and 8 matched controls were analyzed 36 genes were differentially expressed using J5 score and prediction modeling in caGEDA computer program Keywords: snap frozen, banked CVS specimens with known pregnancy outcomes revealed genes differentially expressed in preeclampsia pregnancies

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Epigenome analysis of first trimester CVS samples from normal and Trisomy 13,18,21 pregnancies, and maternal whole blood samples.

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Project description:Rabies virus (RABV) infection led to alteration of microRNA expression in NA and microglia. A sixteen-chip study was performed using total RNA isolated from NA and microglia infected with rabies virus CVS-11 (Challenge virus standard) or mock infected as a control. RNA was isolated from microglia at 12, 24, or 48 hpi and from NA at 24 hpi.

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