Gene expression changes induced by dimerization of intracellular c-Mpl in cord blood CD34+ progenitors

ABSTRACT: Homodimerization of Mpl can also be accomplished in the absence of Tpo, by binding of a synthetic ligand (Chemical inducer of dimerization, CID) to a constitutively expressed fusion protein F36VMpl consisting of a ligand binding domain (F36V) and the intracellular signaling domain of Mpl. In contrast to Tpo stimulation, F36VMpl dimerization in human CD34+ progenitor cells generates robust erythropoiesis. Microarray gene expression profiling of progenitors demonstrated that F36VMpl dimerization, but not Tpo, results in upregulation of critical erythroid genes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE30585 | GEO | 2011/09/01

SECONDARY ACCESSION(S): PRJNA144501

REPOSITORIES: GEO