Cytoplasmic MTDH associates with mRNAs

ABSTRACT: To examine whether MTDH is a novel RNA binding protein and regulates either metabolism or translation of various mRNAs, we performed a RNA-binding protein immunoprecipitation (RIP) with MTDH and IgG antibodies, and the resulting immunoprecipitated RNA was subjected to a microarray to identify transcripts associating with MTDH. In addition we tested the effect of PI3K inhibition using BEZ235 (a dual PI3K/mTOR inhibitor) on the association of MTDH with target mRNAs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE30588 | GEO | 2011/07/13

SECONDARY ACCESSION(S): PRJNA144575

REPOSITORIES: GEO