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Intratumoral plasma cells are required for immune checkpoint blockade therapy in de novo MPNSTs

ABSTRACT: In most human cancers, intratumoral plasma cells connote improved patient survival and heightened anti-tumor response to immune checkpoint blockade (ICB) therapies, such as those targeting programmed death-ligand 1 (PD-L1) or programmed death 1 (PD1). Using an immunocompetent mouse model of de novo malignant peripheral nerve sheath tumors (MPNSTs), we found that plasma cells are required for successful anti-PD-L1 therapy and extended survival. In order to uncover the role of plasma cells in this response, we performed scRNA-seq of de novo MPNSTs within wild-type controls versus plasma cell-deficient AID-/-; µS-/- mice following CDK4/6-MEK inhibition. These results support our hypothesis that response to anti-PD-L1 is influenced by plasma cell infiltration into MPNSTs following CDK4/6-MEK inhibition.

ORGANISM(S): Mus musculus

PROVIDER: GSE306038 | GEO | 2026/08/19

REPOSITORIES: GEO

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