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SPP1+ Macrophages Contribute to Hair Growth in Contact Hypersensitivity [spatial transcriptomics]

ABSTRACT: Using Visium HD spatial transcriptomics and immunostaining, we mapped skin compartment dynamics during DPCP-induced allergic contact dermatitis. Dermal white adipose tissue transitioned from metabolic homeostasis to immune activation and inflammatory remodeling, accompanied by sustained lipolysis. Concurrently, CD45⁺ immune cells accumulated in the lower dermis and dWAT. These findings identify dWAT as an immune-metabolic hub orchestrating inflammatory progression and highlight spatial transcriptomics as a powerful tool for dissecting skin niche regulation.

ORGANISM(S): Mus musculus

PROVIDER: GSE306162 | GEO | 2025/12/01

REPOSITORIES: GEO

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